Isham Webb (d. 1778) was a planter, grist mill owner, and politician from Tyrrell County. He represented Tyrrell at the 5th Provincial Congress in Halifax in 1776 and in the North Carolina General Assembly in 1778. In 1777 he served as security on bonds for Bird Land and Benjamin Moss, who both had to appear before the Court of Oyer & Terminer at Edenton to testify about their involvement in the Gourd Patch Conspiracy.