Louisa Wells May was born in Kentucky in about 1824. A resident of Morgan County, Kentucky, she married Caleb D. May in 1844. May was a justice of the peace and Louisa occasionally acted as a witness in her husband's business proceedings. The Mays had at least five children together. After Caleb D. May died in 1865, she remarried to John F. Little in 1867. She died sometime after 1910.