The Yeopim are an American Indian Nation that reside on the northeastern shore of the Albemarle Sound in North Carolina. The Yeopim, along with the Posteskeet and the Paspatank, descended from the Weapemeoc Indians, a tribe from southern Virginia and northern North Carolina who interacted with the the first English colonists to arrive in the colony in the 16th century. In 1704 the North Carolina set aside a reservation for the Yeopim on the North River in present-day Camden County. By 1739 as their power and population waned, the Yeopim began to sell portions of their land to colonists. They lost a portion of their identity as a tribal nation as the remaining Yeopim integrated into the surrounding Anglo-American society. The Yeopim's reservation, later called Indiantown, continued to be marked on maps through the 19th century.

Efforts at reforming a Yeopim tribal nation in 2013 were unsuccessful, and as of 2024 no Yeopim group has been recognized at the state or federal level.

For more information and links to resources, please see our editorial statement on American Indian terminology.