Margaret "Peggy" Dozier Strozier was born in North Carolina on September 1, 1740. In October 1758 she married Peter Strozier in Rowan County, North Carolina. The couple had at least seven children together. Prior to the American Revolution, the Stroziers moved to Wilkes County, Georgia, where in 1779 Peter enlisted in the local county militia. Peter Strozier served in a cavalry unit under the command of General Elijah Clark and only rarely visited his home and family over the next two years, as Wilkes County had become a loyalist stronghold.

Without her husband's support, Margaret Strozier was responsible for running her family's household and caring for the family's many children. Not only did Margaret Strozier care for her own family, but when General Elijah Clarke's army camped nearby, Margaret Strozier came to where they were staying and helped prepare breakfast for the troops.

By the winter of 1780-1781, Wilkes County had become an increasingly hostile place for Patriot sympathizers. That winter, a group of loyalists attacked the Strozier farm, destroying or stealing everything of value. Without a place to stay or food for the winter, Margaret Strozier carried her children through South Carolina to her husband and the rest of the Patriot army camped in North Carolina. She later reflected that during this period she and her children were "half begging & starving, suffering greatly from want & cold, exposure & raggedness." Peter Strozier continued in service until the war's end, when they returned to Wilkes County, Georgia.

After the war, the Stroziers amassed hundred of acres of land in the vicinity of Wilkes County, Georgia. Her husband died in 1807, and Margaret Strozier never remarried. Although living independently on the 1830 census, by 1840 she was living with her son Reuben in Meriwether County, Georgia. In February 1842 Margaret Strozier submitted an application for a widow's pension based on her husband's service during the Revolution. Before her claim could be approved, she died in the fall of 1842.