James Sitterson was a resident of Perquimans Precinct, North Carolina. In 1720 he purchased an enslaved American Indian at Core Sound from Willowby, a Chowan Indian. He did not pay Willowby, however, and Chief John Hoyter brought a complaint on Willowby's behalf to the North Carolina Council requesting Sitterson's payment. He died in Perquimans in about December 1749.